212 citations · 469 across the 11 of their papers we have counts for
5 papers · 1 filter
Pervasive Flexibility in Living Technologies through Degeneracy Based Design
James Whitacre, Axel Bender
The capacity to adapt can greatly influence the success of systems that need to compensate for damaged parts, learn how to achieve robust performance in new environments, or exploi…
Evolutionary Mechanics: new engineering principles for the emergence of flexibility in a dynamic and uncertain world
James M Whitacre, Philipp Rohlfshagen, Axel Bender +1
Engineered systems are designed to deftly operate under predetermined conditions yet are notoriously fragile when unexpected perturbations arise. In contrast, biological systems op…
Networked buffering: a basic mechanism for distributed robustness in complex adaptive systems
James M Whitacre, Axel Bender
Here we propose a generic mechanism - networked buffering - for generating robust traits in complex systems that requires two basic conditions to be satisfied: 1) agents are versat…
Degeneracy: a link between evolvability, robustness and complexity in biological systems
James Whitacre, Axel Bender
A full accounting of biological robustness remains elusive; both in terms of the mechanisms by which robustness is achieved and the forces that have caused robustness to grow over…
Degeneracy: a design principle for achieving robustness and evolvability
James M Whitacre, Axel Bender
Robustness, the insensitivity of some of a biological system's functionalities to a set of distinct conditions, is intimately linked to fitness. Recent studies suggest that it may…