4 papers
The Value of System 1 Models in Medicine
Xiufeng Yang, Konstantinos Vrettos, Zeineb Ben Chaaben +17
Many clinical decisions are a choice among a few fixed options, taken quickly and in large numbers. Such decisions also need an uncertainty estimate to know when to defer to a clin…
Information-seeking failures of large language models in agentic clinical reasoning
Krischan Braitsch, Laura K. Schmalbrock, Theresa Weltermann +11
Large language models achieve high scores on medical knowledge assessments, yet clinical reasoning requires actively deciding what to investigate under uncertainty. We developed an…
Routine laboratory trajectories encode the onset of organ-level complications in cancer
Jannik Lübberstedt, Krischan Braitsch, Jacqueline Lammert +21
Routine laboratory panels drawn during cancer treatment constitute longitudinal physiological recordings of organ function, yet their temporal structure is discarded by single-time…
Agentic clinical reasoning over longitudinal myeloma records: a retrospective evaluation against expert consensus
Johannes Moll, Jannik Lübberstedt, Christoph Nuernbergk +21
Multiple myeloma is managed through sequential lines of therapy over years to decades, with each decision depending on cumulative disease history distributed across dozens to hundr…