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physics.bio-ph2026
Cell strain-stiffening drives cell breakout from embedded spheroids
Shabeeb Ameen, Kyungeun Kim, Ligesh Theeyancheri +5
Understanding how cells escape from embedded spheroids requires a mechanical framework linking stress generation within cells, across cells, and between cells and the surrounding e…
physics.bio-ph2024
Enhanced extracellular matrix remodeling due to embedded spheroid fluidization
Tao Zhang, Shabeeb Ameen, Sounok Ghosh +5
Tumor spheroids are in vitro three-dimensional, cellular collectives consisting of cancerous cells. Embedding these spheroids in an in vitro fibrous environment, such as a collagen…