8 papers · 1 filter
From simple interactions to complex biology: a hypergraph percolation perspective
Arturo Tozzi
The emergence of biological complexity can be viewed as a transition from fragmented local interactions to extensive integrated organization, raising the question of how large-scal…
Spatial confinement and boundary constraints governing biological chirality: a simulation study
Arturo Tozzi
Biological systems exhibit marked molecular asymmetry, with proteins based predominantly on L-amino acids and nucleic acids and carbohydrates largely composed of D-sugars. Explanat…
An exponential logarithmic measure of drug receptor binding and saturation
Arturo Tozzi
Ligand receptor interactions are commonly assessed through equilibrium occupancy and pharmacodynamic measures that describe binding and saturation by means of bounded response curv…
Tumor containment as an anti-percolation process
Arturo Tozzi
Percolation theory from statistical physics has been applied to several aspects of tumor progression. Tumor growth on percolation clusters has been used to model spatial expansion,…
Energy gradients as potential drivers of pre-cellular chemical organization
Arturo Tozzi
The onset of life is often framed around membrane bound compartments and encoded metabolism, leaving unresolved how spatial organization arose before stable boundaries. In this con…
Baseline glycemia exhibits non-random, history-dependent variation across repeated meals
Arturo Tozzi
Glycemic regulation is often described as maintaining glucose levels near a stable baseline. However, continuous glucose monitoring after meals displays intra-individual variabilit…
Electrokinetic sensing in cartilage: a porous-material perspective on joint mechanics
Arturo Tozzi
Mechanical loading in articular cartilage drives interstitial fluid flow through the porous collagen proteoglycan matrix, generating electrokinetic signals. We investigate whether…
Topological analysis of bladder filling
Arturo Tozzi
Bladder function is typically assessed through pressure volume relations, compliance indices and flow measurements, whereas structural evaluation relies largely on qualitative imag…