most citedA Causal Inference Framework for Leveraging External Controls in Hybrid Trials

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stat.ME2026

Externally Controlled Trials: A Review of Design and Borrowing Through a Causal Lens

Ke Zhu, Rima Izem, Peng Yang +8

Externally controlled trials (ECTs) are increasingly used when randomized controls are infeasible, unethical, or insufficient, including applications in rare diseases, oncology, pe…

stat.ME2023★ 1 cited

A Causal Inference Framework for Leveraging External Controls in Hybrid Trials

Michael Valancius, Herb Pang, Jiawen Zhu +3

We consider the challenges associated with causal inference in settings where data from a randomized trial is augmented with control data from an external source to improve efficie…

stat.ME2023

Case Weighted Adaptive Power Priors for Hybrid Control Analyses with Time-to-Event Data

Evan Kwiatkowski, Jiawen Zhu, Xiao Li +3

We develop a method for hybrid analyses that uses external controls to augment internal control arms in randomized controlled trials (RCT) where the degree of borrowing is determin…