163 citations · 166 across the 4 of their papers we have counts for
4 papers
Vibrational density of states capture the role of dynamic allostery in protein evolution
Tushar Modi, Matthias Heyden, S. Banu Ozkan
Previous studies of the flexibilities of ancestral proteins suggests that proteins evolve their function by altering their native state ensemble. Here we propose a more direct meth…
Information propagation in time through allosteric signaling
Tushar Modi, S. Banu Ozkan, Steve Pressé
Naively, one expects the information communicated by an enzyme downstream within a signaling network, in which the enzyme is embedded, to grow monotonically with the enzyme's rate…
Manipulation of conformational change in proteins by single residue perturbations
C Atilgan, Z N Gerek, S B Ozkan +1
Using the perturbation-response scanning (PRS) technique, we study a set of 23 proteins that display a variety of conformational motions upon ligand binding (e.g. shear, hinge, all…
Essential sub-networks based on contact strength reveal folding kinetics
Taisong Zou, Canan Atilgan, Ali Rana Atilgan +1
It has been observed that the topology of the native state is an important determinant of protein folding kinetics and there is a significant correlation between folding rate and r…