3 papers
q-bio.BM2026
SwitchCraft: A Programmatic Framework for Designing State-Switching Proteins
Bowen Jing, Mihir Bafna, Anisha Parsan +5
Multistate mechanisms underlie many of the complex functions observed in natural proteins. The ability to rationally design multistate proteins would have transformative implicatio…
cs.LG2026
Ambient Dataloops: Generative Models for Dataset Refinement
Adrián RodrÃguez-Muñoz, William Daspit, Adam Klivans +3
We propose Ambient Dataloops, an iterative framework for refining datasets that makes it easier for diffusion models to learn the underlying data distribution. Modern datasets cont…
q-bio.QM2025
Triangle Multiplication Is All You Need For Biomolecular Structure Representations
Jeffrey Ouyang-Zhang, Pranav Murugan, Daniel J. Diaz +7
AlphaFold has transformed protein structure prediction, but emerging applications such as virtual ligand screening, proteome-wide folding, and de novo binder design demand predicti…