6 papers
Spatial Transcriptomics-Guided Alignment Enhances Molecular Profiling in Pathology Foundation Model
Fengtao Zhou, Yingxue Xu, Zhengyu Zhang +20
Comprehensive molecular profiling is essential for modern precision oncology but remains hindered by prohibitive costs, specimen exhaustion, and protracted turnaround times. While…
DXA-Derived Skeletal Phenotypes and Hip Fracture Risk: A Backdoor-Adjusted Causal Analysis
Zixin Shi, Chen Zhao, Meiling Zhou +8
Purpose: To compare dual-energy X-ray absorptiometry (DXA)-derived hip skeletal phenotypes in relation to hip fracture risk using prespecified confounder adjustment and to assess w…
GenoBERT: A Language Model for Accurate Genotype Imputation
Lei Huang, Chuan Qiu, Kuan-Jui Su +13
Genotype imputation enables dense variant coverage for genome-wide association and risk-prediction studies, yet conventional reference-panel methods remain limited by ancestry bias…
PF-DAformer: Proximal Femur Segmentation via Domain Adaptive Transformer for Dual-Center QCT
Rochak Dhakal, Chen Zhao, Zixin Shi +6
Quantitative computed tomography (QCT) plays a crucial role in assessing bone strength and fracture risk by enabling volumetric analysis of bone density distribution in the proxima…
An Advanced Two-Stage Model with High Sensitivity and Generalizability for Prediction of Hip Fracture Risk Using Multiple Datasets
Shuo Sun, Meiling Zhou, Chen Zhao +8
Hip fractures are a major cause of disability, mortality, and healthcare burden in older adults, underscoring the need for early risk assessment. However, commonly used tools such…
ICGM-FRAX: Iterative Cross Graph Matching for Hip Fracture Risk Assessment using Dual-energy X-ray Absorptiometry Images
Chen Zhao, Anjum Shaik, Joyce H. Keyak +7
Hip fractures represent a major health concern, particularly among the elderly, often leading decreased mobility and increased mortality. Early and accurate detection of at risk in…