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stat.ME2025
Network Meta-Analysis of survival outcomes with non-proportional hazards using flexible M-splines
David M. Phillippo, Ayman Sadek, Hugo Pedder +1
Network meta-analysis (NMA) is widely used in healthcare decision-making, where estimates of the effect of multiple treatments on outcomes are required. For time-to-event outcomes…
stat.ME2025
Marginal and conditional summary measures: transportability and compatibility across studies
Antonio Remiro-Azócar, David M. Phillippo, Nicky J. Welton +4
Marginal and conditional summary measures do not generally coincide, have different interpretations and correspond to different decision questions. While these aspects have primari…
stat.ME2024
Effect modification and non-collapsibility leads to conflicting treatment decisions: a review of marginal and conditional estimands and recommendations for decision-making
David M. Phillippo, Antonio Remiro-Azócar, Antonio Remiro-Azócar +5
Effect modification occurs when a covariate alters the relative effectiveness of treatment compared to control. It is widely understood that, when effect modification is present, t…