4 papers
Fast Generalization after Interpolation via Critically Damped Momentum Optimization
Luca Muscarnera, Silas Ruhrberg Estévez, Yuanzhang Xiao +1
A central problem in machine learning is that models can achieve near-perfect training performance while generalizing substantially less well to unseen examples. This gap is especi…
Knowledge-Informed Kernel State Reconstruction from Heterogeneous Partial Observations
Luca Muscarnera, Silas Ruhrberg Estévez, Samuel Holt +2
Real-world scientific systems are rarely observed through complete, regularly sampled state trajectories. Instead, measurements are often partial, noisy, and heterogeneous, providi…
CellBRIDGE: Learning Cellular Trajectories via Interaction-Aware Alignment
Silas Ruhrberg Estévez, Nicolas Huynh, Tennison Liu +4
Inferring dynamics from population snapshots is a fundamental challenge in machine learning and biology. In scRNA-sequencing (scRNA-seq), destructive measurements preclude direct t…
Automatic Construction of Clinical Scoring Systems with LLM Agents
Silas Ruhrberg Estévez, Christopher Chiu, Mihaela van der Schaar
Modern clinical practice relies on evidence-based guidelines implemented as compact scoring systems composed of a small number of interpretable decision rules. While machine-learni…