29 citations · 29 across the 4 of their papers we have counts for
4 papers
Nonlinear regulation of commitment to apoptosis by simultaneous inhibition of Bcl-2 and XIAP in leukemia and lymphoma cells
Joanna Skommer, Somkanya C Das, Arjun Nair +2
Apoptosis is a complex pathway regulated by the concerted action of multiple pro- and anti-apoptotic molecules. The intrinsic (mitochondrial) pathway of apoptosis is governed up-st…
Timing is everything: on the stochastic origins of cell-to-cell variability in cancer cell death decisions
Joanna Skommer, Subhadip Raychaudhuri, Donald Wlodkowic
The diversity of cell populations is regulated by extracellular and intracellular variability. The latter includes genetic, epigenetic and stochastic variability, all contributing…
Discrimination of Membrane Antigen Affinity by B cells Requires Dominance of Kinetic Proofreading over Serial Triggering
Philippos K. Tsourkas, Wanli Liu, Somkanya C Das +2
B cells receptor (BCR) signaling in response to membrane-bound antigen increases with antigen affinity, a process known as affinity discrimination. We use computational modeling to…
A Minimal Model of Signaling Network Elucidates Cell-to-Cell Stochastic Variability in Apoptosis
Subhadip Raychaudhuri
Signaling networks are designed to sense an environmental stimulus and adapt to it. We propose and study a minimal model of signaling network that can sense and respond to external…