most citedScalable Single-Cell Gene Expression Generation with Latent Diffusion Models

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cs.CE2026

Cell-JEPA: Latent Representation Learning for Single-Cell Transcriptomics

Ali ElSheikh, Rui-Xi Wang, Weimin Wu +9

Single-cell foundation models learn by reconstructing masked gene expression, implicitly treating technical noise as signal. With dropout rates exceeding 90%, reconstruction object…