3 papers
q-bio.BM2024
Hotspot-Driven Peptide Design via Multi-Fragment Autoregressive Extension
Jiahan Li, Tong Chen, Shitong Luo +7
Peptides, short chains of amino acids, interact with target proteins, making them a unique class of protein-based therapeutics for treating human diseases. Recently, deep generativ…
q-bio.BM2024
Full-Atom Peptide Design based on Multi-modal Flow Matching
Jiahan Li, Chaoran Cheng, Zuofan Wu +5
Peptides, short chains of amino acid residues, play a vital role in numerous biological processes by interacting with other target molecules, offering substantial potential in drug…
cs.LG2024
Categorical Flow Matching on Statistical Manifolds
Chaoran Cheng, Jiahan Li, Jian Peng +1
We introduce Statistical Flow Matching (SFM), a novel and mathematically rigorous flow-matching framework on the manifold of parameterized probability measures inspired by the resu…