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q-bio.QM2025
Dynamic response phenotypes and model discrimination in systems and synthetic biology
Eduardo D. Sontag
Biological systems encode function not primarily in steady states, but in the structure of transient responses elicited by time-varying stimuli. Overshoots, biphasic dynamics, adap…
physics.bio-ph2025
Dynamics and dose response in scaffold ligand binding
Eduardo D. Sontag
This paper considers systems in which two or more ligands bind independently to a common scaffold. Such systems arise in a range of applications, including immunotherapy and synthe…