most citedStatistical Operating Characteristics of Current Early Phase Dose Finding Designs with Toxicity and Efficacy in Oncology

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Statistical Operating Characteristics of Current Early Phase Dose Finding Designs with Toxicity and Efficacy in Oncology

Hao Sun, Hsin-Yu Lin, Jieqi Tu +2

Traditional phase I dose finding cancer clinical trial designs aim to determine the maximum tolerated dose (MTD) of the investigational cytotoxic agent based on a single toxicity o…