3 papers
stat.ME2024
Assessing the replicability of RCTs in RWE emulations
Jeanette Köppe, Charlotte Micheloud, Stella Erdmann +2
Background: The standard regulatory approach to assess replication success is the two-trials rule, requiring both the original and the replication study to be significant with effe…
stat.AP2024
The assessment of replicability using the sum of p-values
Leonhard Held, Samuel Pawel, Charlotte Micheloud
Statistical significance of both the original and the replication study is a commonly used criterion to assess replication attempts, also known as the two-trials rule in drug devel…
stat.ME2023
Replication of "null results" -- Absence of evidence or evidence of absence?
Samuel Pawel, Rachel Heyard, Charlotte Micheloud +1
In several large-scale replication projects, statistically non-significant results in both the original and the replication study have been interpreted as a "replication success".…