38 citations · 52 across the 8 of their papers we have counts for
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q-bio.SC2024
Target search in the CRISPR/Cas9 system: Facilitated diffusion with target cues
Qiao Lu, Simone Pigolotti
We study how Cas9, a central component of the CRISPR/Cas9 system, searches for a target sequence on the DNA. We propose a model that includes as key ingredients 3D diffusion, 1D sl…
q-bio.SC2023★ 3 cited
Genome replication in asynchronously growing microbial populations
Florian Pflug, Deepak Bhat, Simone Pigolotti
Biological cells replicate their genomes in a well-planned manner. The DNA replication program of an organism determines the timing at which different genomic regions are replicate…