4 papers
Fluctuating environments are sufficient to drive substantial variability in species abundance across locations
James F. D. Henderson, Andreas Tiffeau-Mayer
Species growing in environments that change in time and space will vary in their abundance across locations, even in the absence of persistent location preferences. Here we quantif…
Data-driven Discovery of Biophysical T Cell Receptor Co-specificity Rules
Andrew G. T. Pyo, Yuta Nagano, Martina Milighetti +5
The biophysical interactions between the T cell receptor (TCR) and its ligands determine the specificity of the cellular immune response. However, the immense diversity of receptor…
Contrastive learning of T cell receptor representations
Yuta Nagano, Andrew Pyo, Martina Milighetti +4
Computational prediction of the interaction of T cell receptors (TCRs) and their ligands is a grand challenge in immunology. Despite advances in high-throughput assays, specificity…
Limits on Inferring T-cell Specificity from Partial Information
James Henderson, Yuta Nagano, Martina Milighetti +1
A key challenge in molecular biology is to decipher the mapping of protein sequence to function. To perform this mapping requires the identification of sequence features most infor…