4 papers
A software tool for parametric collimator creation for linac-based preclinical irradiation studies
Joseph B. Schulz, Dixin Chen, Lloyd Emmanuel Kamole Ghomsi +5
Designing custom Cerrobend collimators for linac-based preclinical electron irradiation is labor intensive and susceptible to design inconsistencies. We developed Collimator Creato…
Addressing respiratory gating latency for accurate pulse delivery in preclinical electron FLASH irradiation on a clinical linear accelerator
Rakesh Manjappa, Jinghui Wang, Stavros Melemenidis +15
Background: Clinical linear accelerators are an accessible platform for preclinical research on the biological effects of ultra rapid electron irradiation (FLASH). However, they ar…
Preclinical Water-Mediated Ultrasound Platform using Clinical FOV for Molecular Targeted Contrast-Enhanced Ultrasound
Stavros Melemenidis, Anna Stephanie Kim, Jenny Vo-Phamhi +3
Background: This protocol introduces an ultrasound (US) configuration for whole-body 3D dynamic contrast-enhanced ultrasound (DCE-US) imaging in preclinical applications. The set-u…
Dosimetric calibration of an anatomically specific ultra-high dose rate electron irradiation platform for preclinical FLASH radiobiology experiments
Jinghui Wang, Stavros Melemenidis, Rakesh Manjappa +16
We characterized the dosimetric properties of a clinical linear accelerator configured to deliver ultra-high dose rate (UHDR) irradiation to mice and cell-culture FLASH radiobiolog…