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stat.ME2023
Individual participant data from digital sources informed and improved precision in the evaluation of predictive biomarkers in Bayesian network meta-analysis
Chinyereugo M Umemneku-Chikere, Lorna Wheaton, Heather Poad +7
Objective: We aimed to develop a meta-analytic model for evaluation of predictive biomarkers and targeted therapies, utilising data from digital sources when individual participant…
stat.ME2023
Bayesian meta-analysis for evaluating treatment effectiveness in biomarker subgroups using trials of mixed patient populations
Lorna Wheaton, Dan Jackson, Sylwia Bujkiewicz
During drug development, evidence can emerge to suggest a treatment is more effective in a specific patient subgroup. Whilst early trials may be conducted in biomarker-mixed popula…