9 papers
An Octahedral Fibrous Constitutive Model for Heart Valve Mechanics and Function
Nishan Parvez, Prashant K. Purohit, Wensi Wu
Fibrous soft tissues derive their nonlinear mechanical response from networks of extracellular matrix fibers, whose organization gives rise to strain stiffening, the reverse Poynti…
A geometric feature tracking approach for noninvasive patient specific estimation of leaflet strain from 3D images of heart valves
Wensi Wu, Matthew Daemer, Jeffrey A. Weiss +2
Valvular heart disease is prevalent and a major contributor to heart failure. Valve leaflet strain is a promising metric for evaluating the mechanics underlying the initiation and…
An open-source computational framework for immersed fluid-structure interaction modeling using FEBio and MFEM
Ryan T. Black, Steve A. Maas, Wensi Wu +4
Fluid-structure interaction (FSI) simulation of biological systems presents significant computational challenges, particularly for applications involving large structural deformati…
Biomechanically Informed Image Registration for Patient-Specific Aortic Valve Strain Analysis
Mohsen Nakhaei, Alison Pouch, Silvani Amin +8
Aortic valve (AV) biomechanics play a critical role in maintaining normal cardiac function. Pathological variations, particularly in bicuspid aortic valves, alter leaflet loading,…
Effect of Right Ventricular Outflow Tract Material Properties on Simulated Transcatheter Pulmonary Placement
Jalaj Maheshwari, Wensi Wu, Christopher N. Zelonis +9
Finite element (FE) simulations emulating transcatheter pulmonary valve (TPV) system deployment in patient-specific right ventricular outflow tracts (RVOT) assume material properti…
Integrated Open-Source Framework for Simulation of Transcatheter Pulmonary Valves in Native Right Ventricular Outflow Tracts
Christopher N. Zelonis, Jalaj Maheshwari, Wensi Wu +14
Background - Pulmonary insufficiency is a consequence of transannular patch repair in Tetralogy of Fallot (ToF), leading to late morbidity and mortality. Transcatheter native outfl…