4 papers · 1 filter
A Unified Framework for Multiple Exposure Distributed Lag Non-Linear Models for Air Pollution Epidemiology
Tianyi Pan, Hwashin Hyun Shin, Alex Stringer +1
This study quantifies the association between air pollution and mortality in Ontario, Canada. Exposure-response relationships in air pollution epidemiology are complex due to three…
Inference for generalized additive mixed models via penalized marginal likelihood
Alex Stringer
The Laplace approximation is sometimes not sufficiently accurate for smoothing parameter estimation in generalized additive mixed models. A novel estimation strategy is proposed th…
Semi-parametric Benchmark Dose Analysis with Monotone Additive Models
Alex Stringer, Tugba Akkaya Hocagil, Richard Cook +3
Benchmark dose analysis aims to estimate the level of exposure to a toxin that results in a clinically-significant adverse outcome and quantifies uncertainty using the lower limit…
Exact Gradient Evaluation for Adaptive Quadrature Approximate Marginal Likelihood in Mixed Models for Grouped Data
Alex Stringer
A method is introduced for approximate marginal likelihood inference via adaptive Gaussian quadrature in mixed models with a single grouping factor. The core technical contribution…