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20242026
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stat.ME2026

A Review of Methods and Practices for Missing Data in Sequential Multiple Assignment Randomized Trials (SMARTs): An Ancillary Study of a Scoping Review

Nikki L. B. Freeman, Chenyao Yu, Margaret Hoch +5

Background: Missing data poses an acute threat to sequential multiple assignment randomized trial (SMART) analyses because of the sequential treatment structure and response-depend…

stat.ME2025

Robust and Efficient Semiparametric Inference for the Stepped Wedge Design

Fan Xia, K. C. Gary Chan, Emily Voldal +3

Stepped wedge designs (SWDs) are increasingly used to evaluate longitudinal cluster-level interventions but pose substantial challenges for valid inference. Because crossover times…

stat.ME2025

Factors affecting power in stepped wedge trials when the treatment effect varies with time

Avi Kenny, Emily C. Voldal, Fan Xia +3

Stepped wedge cluster randomized trials (SW-CRTs) have historically been analyzed using immediate treatment (IT) models, which assume the effect of the treatment is immediate after…

stat.ME2024

Repeated sampling of different individuals within the same clusters to improve precision of longitudinal estimators: the DISC design

Jordan Downey, Avi Kenny

Background: Longitudinal studies often involve repeated cluster sampling of a population at multiple time points, such as in difference-in-differences (DID) studies. Although cohor…

stat.ME2024

Analysis of Stepped-Wedge Cluster Randomized Trials when treatment effects vary by exposure time or calendar time

Kenneth M. Lee, Elizabeth L. Turner, Avi Kenny

Stepped-wedge cluster randomized trials (SW-CRTs) are traditionally analyzed with models that assume an immediate and sustained treatment effect. Previous work has shown that makin…