3 papers
stat.ME2026
Assessing the Impact of Intercurrent Events on Power and Sample Size for Estimands with Time-to-Event Endpoints
Daniel J Bratton, Fiona Guillard, Sunita Rehal +1
The precise definition of a primary estimand, accounting for intercurrent events (IEs) as per the ICH E9(R1) addendum, is fundamental to the design and interpretation of clinical t…
stat.ME2025
Using off-treatment sequential multiple imputation for binary outcomes to address intercurrent events handled by a treatment policy strategy
Sunita Rehal, Nicky Best, Sarah Watts +1
The estimand framework proposes different strategies to address intercurrent events. The treatment policy strategy seems to be the most favoured as it is closely aligned with the p…
stat.ME2024
The Estimand Framework and Causal Inference: Complementary not Competing Paradigms
Thomas Drury, Jonathan W. Bartlett, David Wright +1
The creation of the ICH E9 (R1) estimands framework has led to more precise specification of the treatment effects of interest in the design and statistical analysis of clinical tr…