6 papers
Energetics, shearing and pumping efficiency of propagating contractions over villi-patterned wall
Rohan Vernekar, Claude Loverdo, Stéphane Tanguy +1
Intestinal villi undergo pendular-wave motility -- an active, propagating tissue motion driven by underlying longitudinal muscles. This motility drives irreversible, counter-wave f…
Environment heterogeneity creates fast amplifiers of natural selection in graph-structured populations
Cecilia Fruet, Arthur Alexandre, Alia Abbara +2
Complex spatial structure, with partially isolated subpopulations, and environment heterogeneity, such as gradients in nutrients, oxygen, and drugs, both shape the evolution of nat…
Hydrodynamics in a villi-patterned channel due to pendular-wave activity
Rohan Vernekar, Faisal Ahmad, Martin Garic +4
Inspired by small intestine motility, we investigate the flow induced by a propagating pendular-wave along the walls of a channel lined with rigid, villi-like microstructures. The…
Intestinal villi and crypts density maximizing nutrient absorption
Martin Garic, Rohan Vernekar, Dácil I. Yánez MartÃn +3
The villi and crypts of the gastrointestinal tract increase the effective surface area of the intestinal mucosa, potentially enhancing nutrient absorption. It is commonly assumed t…
Spatial structure facilitates evolutionary rescue by drug resistance
Cecilia Fruet, Ella Linxia Müller, Claude Loverdo +1
Bacterial populations often have complex spatial structures, which can impact their evolution. Here, we study how spatial structure affects the evolution of antibiotic resistance i…
Bridging Wright-Fisher and Moran models
Arthur Alexandre, Alia Abbara, Cecilia Fruet +2
The Wright-Fisher model and the Moran model are both widely used in population genetics. They describe the time evolution of the frequency of an allele in a well-mixed population w…