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stat.ME2024
Sparse two-stage Bayesian meta-analysis for individualized treatments
Junwei Shen, Erica E. M. Moodie, Shirin Golchi
Individualized treatment rules tailor treatments to patients based on clinical, demographic, and other characteristics. Estimation of individualized treatment rules requires the id…
stat.ME2024
An adaptive enrichment design using Bayesian model averaging for selection and threshold-identification of tailoring variables
Lara Maleyeff, Shirin Golchi, Erica E. M. Moodie +1
Precision medicine stands as a transformative approach in healthcare, offering tailored treatments that can enhance patient outcomes and reduce healthcare costs. As understanding o…
stat.ME2024
Bayesian Optimization for Identification of Optimal Biological Dose Combinations in Personalized Dose-Finding Trials
James Willard, Shirin Golchi, Erica EM Moodie
Early phase, personalized dose-finding trials for combination therapies seek to identify patient-specific optimal biological dose (OBD) combinations, which are defined as safe dose…