3 papers
q-bio.BM2026
AlloGen: Conformation-Selective Binder Generation with Differential State Scoring
Hanqun Cao, Zachary Quinn, Aastha Pal +4
Protein binder design has largely optimized for affinity alone, leaving conformational selectivity unaddressed: for allosteric targets such as kinases, nuclear receptors, and GPCRs…
q-bio.BM2026
TD3B: Transition-Directed Discrete Diffusion for Allosteric Binder Generation
Hanqun Cao, Aastha Pal, Sophia Tang +4
Protein function is often controlled by ligands that bias the direction of state transitions, such as agonists and antagonists, rather than stabilizing a single conformation. This…
q-bio.BM2024
PepDoRA: A Unified Peptide Language Model via Weight-Decomposed Low-Rank Adaptation
Leyao Wang, Rishab Pulugurta, Pranay Vure +3
Peptide therapeutics, including macrocycles, peptide inhibitors, and bioactive linear peptides, play a crucial role in therapeutic development due to their unique physicochemical p…