2 papers
q-bio.BM2026
AlloGen: Conformation-Selective Binder Generation with Differential State Scoring
Hanqun Cao, Zachary Quinn, Aastha Pal +4
Protein binder design has largely optimized for affinity alone, leaving conformational selectivity unaddressed: for allosteric targets such as kinases, nuclear receptors, and GPCRs…
cs.LG2024
Steering Masked Discrete Diffusion Models via Discrete Denoising Posterior Prediction
Jarrid Rector-Brooks, Mohsin Hasan, Zhangzhi Peng +9
Generative modeling of discrete data underlies important applications spanning text-based agents like ChatGPT to the design of the very building blocks of life in protein sequences…