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q-bio.PE2026
Modeling Protein Evolution with Generative Models: from Extant Sequence Data to Evolutionary Dynamics
Matteo Bisardi, Leonardo Di Bari, Saverio Rossi +3
Protein sequences carry a record of evolutionary history shaped by mutation, selection, drift, and epistasis. Recent generative models trained on homologous sequence families offer…
q-bio.PE2026
Reconstructability of evolutionary intermediates in generative epistatic landscapes
Roberto Netti, Martin Weigt
Evolutionary intermediates connect observed proteins, but the sequence of steps that produced them is rarely recoverable from extant data alone. Here we ask what can, and cannot, b…