2 papers
stat.ME2026
Meta-analysis and network meta-analysis of time-to-event outcomes with non-proportional hazards: a Bayesian time-varying hazard ratio approach
Rhiannon K Owen, Keith R Abrams
Background: Often when undertaking meta-analyses of time-to-event (TTE) outcomes, especially in a Health Technology Assessment context, a hazard ratio (HR) scale is used. However,…
stat.AP2025
Evaluating amyloid-beta as a surrogate endpoint in trials of anti-amyloid drugs in Alzheimer's disease: a Bayesian meta-analysis
Sa Ren, Janharpreet Singh, Sandro Gsteiger +8
The use of amyloid-beta (A) clearance to support regulatory approvals of drugs in Alzheimer's disease (AD) remains controversial. We evaluate A as a potential trial-level sur…