3 papers · 1 filter
The Integration Host Factor is a pH-responsive protein that switches from DNA bending to DNA bridging in acidic biofilm-like conditions
Dinesh Parthasarathy, Saminathan Ramakrishnan, Georgia Tsang +9
The Integration Host Factor (IHF) is a nucleoid-associated protein critical for both DNA compaction and biofilm stability. While its role in DNA packaging within the cell is well u…
Organisation and dynamics of individual DNA segments in topologically complex genomes
Saminathan Ramakrishnan, Auro Varat Patnaik, Guglielmo Grillo +2
Capturing the physical organisation and dynamics of genomic regions is one of the major open challenges in biology. The kinetoplast DNA (kDNA) is a topologically complex genome, ma…
Single-Molecule Morphology of Topologically Digested Olympic Networks
Saminathan Ramakrishnan, Zihao Chen, Yair Augusto Gutierrez Fosado +5
The kinetoplast DNA (kDNA) is the archetype of a two-dimensional Olympic network, composed of thousands of DNA minicircles and found in the mitochondrion of certain parasites. The…