2 papers
stat.AP2025
Dose optimization design accounting for unknown patient heterogeneity in cancer clinical trials
Rebecca B. Silva, Bin Cheng, Shing M. Lee
Project Optimus, an initiative by the FDA's Oncology Center of Excellence, seeks to reform the dose-optimization and dose-selection paradigm in oncology. We propose a dose-optimiza…
stat.AP2023
Precision Dose-finding Cancer Clinical Trials in the Setting of Broadened Eligibility
Rebecca B. Silva, Bin Cheng, Richard D. Carvajal +1
Broadening eligibility criteria in cancer trials has been advocated to represent the true patient population more accurately. While the advantages are clear in terms of generalizab…