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math.DS2026
Combining standard chemoradiotherapy with CAR-T cell therapy in malignant gliomas: Insights from an impulsive mathematical framework and virtual trials
Dmitry Sinelshchikov, Nikols Amaru Mora Millán, Miguel Perales-Patón +2
The extreme therapeutic resistance of malignant gliomas motivates the development of multimodal treatment strategies. We present a mechanistic mathematical framework to investigate…
math.DS2025★ 5 cited
A mathematical model of CAR-T cell therapy in combination with chemotherapy for malignant gliomas
Dmitry Sinelshchikov, Juan Belmonte-Beitia, Matteo Italia
We study the dynamics and interactions between combined chemotherapy and chimeric antigen receptor (CAR-T) cells therapy and malignant gliomas (MG). MG is one of the most common pr…