98 citations · 217 across the 14 of their papers we have counts for
16 papers
In distributive phosphorylation catalytic constants enable non-trivial dynamics
Carsten Conradi, Maya Mincheva
Ordered distributive double phosphorylation is a recurrent motif in intracellular signaling and control. It is either sequential (where the site phosphorylated last is dephosphoryl…
Dynamics of ERK regulation in the processive limit
Carsten Conradi, Nida Obatake, Anne Shiu +1
We consider a model of extracellular signal-regulated kinase (ERK) regulation by dual-site phosphorylation and dephosphorylation, which exhibits bistability and oscillations, but l…
On the existence of Hopf bifurcations in the sequential and distributive double phosphorylation cycle
Carsten Conradi, Elisenda Feliu, Maya Mincheva
Protein phosphorylation cycles are important mechanisms of the post translational modification of a protein and as such an integral part of intracellular signaling and control. We…
Multistationarity in the space of total concentrations for systems that admit a monomial parametrization
Carsten Conradi, Alexandru Iosif, Thomas Kahle
We apply tools from real algebraic geometry to the problem of multistationarity of chemical reaction networks. A particular focus is on the case of reaction networks whose steady s…
Emergence of oscillations in a mixed-mechanism phosphorylation system
Carsten Conradi, Maya Mincheva, Anne Shiu
This work investigates the emergence of oscillations in one of the simplest cellular signaling networks exhibiting oscillations, namely, the dual-site phosphorylation and dephospho…
Dynamics of post-translational modification systems: recent progress and future directions
Carsten Conradi, Anne Shiu
Post-translational modification (PTM) of proteins plays a key role in signal transduction, and hence significant effort has gone toward understanding how PTM networks process infor…