2 papers
stat.ME2025
CUI-MET: Clinical Utility Index Dose Optimization Approach for Multiple-Dose, Multiple-Outcome Randomized Trial Designs
Fanni Zhang, Kristine Broglio, Michael Sweeting +1
Dose optimization in oncology clinical trials has shifted from seeking the maximum tolerated dose to identifying the Optimal Biological Dose (OBD) that balances therapeutic benefit…
stat.AP2023
Optimal risk-assessment scheduling for primary prevention of cardiovascular disease
Francesca Gasperoni, Christopher H. Jackson, Angela M. Wood +4
In this work, we introduce a personalised and age-specific Net Benefit function, composed of benefits and costs, to recommend optimal timing of risk assessments for cardiovascular…