4 papers
Informational blueprints reveal condition-dependent gene regulatory architectures
Doruk Efe Gökmen, Rosalind Wenshan Pan, Tom Röschinger +4
While coding regions in the genome have a direct interpretation in terms of protein products, significant fractions are non-coding and yet control essential biological functions. U…
The Environment-Dependent Regulatory Landscape of the E. coli Genome
Tom Röschinger, Heun Jin Lee, Rosalind Wenshan Pan +7
All cells respond to changes in both their internal milieu and the environment around them through the regulation of their genes. Despite decades of effort, there remain huge gaps…
Deciphering regulatory architectures from synthetic single-cell expression patterns
Rosalind Wenshan Pan, Tom Roeschinger, Kian Faizi +2
For the vast majority of genes in sequenced genomes, there is limited understanding of how they are regulated. Without such knowledge, it is not possible to perform a quantitative…
Force Propagation in Active Cytoskeletal Networks
Shichen Liu, Rosalind Wenshan Pan, Heun Jin Lee +6
In biological systems, molecular-scale forces and motions are pivotal for enabling processes like motility, shape change, and replication. These forces and motions are organized, a…