239 citations · 996 across the 29 of their papers we have counts for
8 papers · 1 filter
Stochastic modeling of phenotypic switching and chemoresistance in cancer cell populations
Niraj Kumar, Gwendolyn M. Cramer, Seyed Alireza Zamani Dahaj +3
Phenotypic heterogeneity in cancer cells is widely observed and is often linked to drug resistance. In several cases, such heterogeneity in drug sensitivity of tumors is driven by…
Transcriptional bursting in gene expression: analytical results for general stochastic models
Niraj Kumar, Abhyudai Singh, Rahul V. Kulkarni
Gene expression in individual cells is highly variable and sporadic, often resulting in the synthesis of mRNAs and proteins in bursts. Bursting in gene expression is known to impac…
Exact distributions for stochastic gene expression models with bursting and feedback
Niraj Kumar, Thierry Platini, Rahul V. Kulkarni
Stochasticity in gene expression can give rise to fluctuations in protein levels and lead to phenotypic variation across a population of genetically identical cells. Recent experim…
Exact protein distributions for stochastic models of gene expression using partitioning of Poisson processes
Hodjat Pendar, Thierry Platini, Rahul V. Kulkarni
Stochasticity in gene expression gives rise to fluctuations in protein levels across a population of genetically identical cells. Such fluctuations can lead to phenotypic variation…
Stochastic modeling of regulation of gene expression by multiple small RNAs
Charles Baker, Tao Jia, Rahul V. Kulkarni
A wealth of new research has highlighted the critical roles of small RNAs (sRNAs) in diverse processes such as quorum sensing and cellular responses to stress. The pathways control…
Computational modeling of differences in the quorum sensing induced luminescence phenotypes of \textit{Vibrio harveyi} and \textit{Vibrio cholerae}
Andrew T Fenley, Suman K Banik, Rahul V Kulkarni
\textit{Vibrio harveyi} and \textit{Vibrio cholerae} have quorum sensing pathways with similar design and highly homologous components including multiple small RNAs (sRNAs). Howeve…