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Geometry-First Generative Spatial Single-Cell Reconstruction
Ehtesamul Azim, Muhtasim Noor Alif, Tae Hyun Hwang +2
Single-cell RNA sequencing (scRNA-seq) profiles large numbers of cells but loses spatial context, whereas spatial transcriptomics (ST) preserves partial spatial structure at lower…
Biological Pathway Guided Gene Selection Through Collaborative Reinforcement Learning
Ehtesamul Azim, Dongjie Wang, Tae Hyun Hwang +2
Gene selection in high-dimensional genomic data is essential for understanding disease mechanisms and improving therapeutic outcomes. Traditional feature selection methods effectiv…
Feature Interaction Aware Automated Data Representation Transformation
Ehtesamul Azim, Dongjie Wang, Kunpeng Liu +2
Creating an effective representation space is crucial for mitigating the curse of dimensionality, enhancing model generalization, addressing data sparsity, and leveraging classical…