4 papers
Platelet plug microstructure and flow modulate fibrin gelation dynamics: Insights from computational simulations
Janneke M. H. Cruts, Frank J. H. Gijsen, Aaron L. Fogelson +1
During the formation of a thrombus, the architecture of the growing platelet aggregate is heterogeneous, with areas of dense and loosely packed platelets. The surface of activated…
Nucleation feedback can drive establishment and maintenance of biased microtubule polarity in neurites
Hannah G. Scanlon, Gibarni Mahata, Anna C. Nelson +3
The microtubule cytoskeleton is comprised of dynamic, polarized filaments that facilitate transport within the cell. Polarized microtubule arrays are key to facilitating cargo tran…
Emergent microtubule properties in a model of filament turnover and nucleation
Anna C. Nelson, Scott A. McKinley, Melissa M. Rolls +1
Microtubules (MTs) are dynamic protein filaments essential for intracellular organization and transport, particularly in long-lived cells such as neurons. The plus and minus ends o…
Minimal Mechanisms of Microtubule Length Regulation in Living Cells
Anna C Nelson, Melissa M Rolls, Maria-Veronica Ciocanel +1
The microtubule cytoskeleton is responsible for sustained, long-range intracellular transport of mRNAs, proteins, and organelles in neurons. Neuronal microtubules must be stable en…