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cs.LG2025
PPDiff: Diffusing in Hybrid Sequence-Structure Space for Protein-Protein Complex Design
Zhenqiao Song, Tiaoxiao Li, Lei Li +1
Designing protein-binding proteins with high affinity is critical in biomedical research and biotechnology. Despite recent advancements targeting specific proteins, the ability to…
cs.LG2025★ 1 cited
InstructPro: Natural Language Guided Ligand-Binding Protein Design
Zhenqiao Song, Ramith Hettiarachchi, Chuan Li +2
The de novo design of ligand-binding proteins with tailored functions is essential for advancing biotechnology and molecular medicine, yet existing AI approaches are limited by sca…