activity
20222026
most citedA comprehensive and biophysically detailed computational model of the whole human heart electromechanics

120 citations · 193 across the 14 of their papers we have counts for

collaborators

14 papers

physics.flu-dyn2026

svMultiPhysics: a finite element-based solver for cardiovascular simulations

David Codoni, Sujal Dave, David W. Parker +10

Heart disease remains the leading cause of death in the United States, motivating extensive efforts to improve its diagnosis, treatment, and prevention. Over the past decade, compu…

math.NA2025

Coupling models of resistive valves to muscle mechanics in cardiac fluid-structure interaction simulations

Michele Bucelli, Luca Dede'

To accurately simulate all phases of the cardiac cycle, computational models of hemodynamics in heart chambers need to include a sufficiently faithful model of cardiac valves. This…

math.NA2025

Influence of cellular mechano-calcium feedback in numerical models of cardiac electromechanics

Irena Radišić, Francesco Regazzoni, Michele Bucelli +3

Multiphysics and multiscale mathematical models enable the non-invasive study of cardiac function. These models often rely on simplifying assumptions that neglect certain biophysic…

math.NA2024

Coupled Eikonal problems to model cardiac reentries in Purkinje network and myocardium

Samuele Brunati, Michele Bucelli, Roberto Piersanti +2

We propose a novel partitioned scheme based on Eikonal equations to model the coupled propagation of the electrical signal in the His-Purkinje system and in the myocardium for card…

math.NA2024

The lifex library version 2.0

Michele Bucelli

This article presents updates to lifex [Africa, SoftwareX (2022)], a C++ library for high-performance finite element simulations of multiphysics, multiscale and multidomain problem…

math.NA2024

Robust radial basis function interpolation based on geodesic distance for the numerical coupling of multiphysics problems

Michele Bucelli, Francesco Regazzoni, Luca Dede' +1

Multiphysics simulations frequently require transferring solution fields between subproblems with non-matching spatial discretizations, typically using interpolation techniques. St…

math.NA2023

lifex-ep: a robust and efficient software for cardiac electrophysiology simulations

Pasquale C. Africa, Roberto Piersanti, Francesco Regazzoni +6

Simulating the cardiac function requires the numerical solution of multi-physics and multi-scale mathematical models. This underscores the need for streamlined, accurate, and high-…

math.NA2023

Preserving the positivity of the deformation gradient determinant in intergrid interpolation by combining RBFs and SVD: application to cardiac electromechanics

Michele Bucelli, Francesco Regazzoni, Luca Dede' +1

The accurate robust and efficient transfer of the deformation gradient tensor between meshes of different resolution is crucial in cardiac electromechanics simulations. We present…

physics.flu-dyn2023★ 2 cited

lifex-cfd: an open-source computational fluid dynamics solver for cardiovascular applications

Pasquale Claudio Africa, Ivan Fumagalli, Michele Bucelli +4

Computational fluid dynamics (CFD) is an important tool for the simulation of the cardiovascular function and dysfunction. Due to the complexity of the anatomy, the transitional re…

math.NA2023★ 49 cited

An electromechanics-driven fluid dynamics model for the simulation of the whole human heart

Alberto Zingaro, Michele Bucelli, Roberto Piersanti +3

We introduce a multiphysics and geometric multiscale computational model, suitable to describe the hemodynamics of the whole human heart, driven by a four-chamber electromechanical…

math.NA2022★ 17 cited

A stable loosely-coupled scheme for cardiac electro-fluid-structure interaction

Michele Bucelli, Martin Geraint Gabriel, Giacomo Gigante +2

We present a loosely coupled scheme for the numerical simulation of the cardiac electro-fluid-structure interaction problem, whose solution is typically computationally intensive d…

math.NA2022★ 1 cited

Modeling isovolumetric phases in cardiac flows by an Augmented Resistive Immersed Implicit Surface Method

Alberto Zingaro, Michele Bucelli, Ivan Fumagalli +2

A major challenge in the computational fluid dynamics modeling of the heart function is the simulation of isovolumetric phases when the hemodynamics problem is driven by a prescrib…

math.NA2022★ 4 cited

A mathematical model that integrates cardiac electrophysiology, mechanics and fluid dynamics: application to the human left heart

Michele Bucelli, Alberto Zingaro, Pasquale Claudio Africa +3

We propose a mathematical and numerical model for the simulation of the heart function that couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and in…

math.NA2022★ 120 cited

A comprehensive and biophysically detailed computational model of the whole human heart electromechanics

Marco Fedele, Roberto Piersanti, Francesco Regazzoni +6

While ventricular electromechanics is extensively studied, four-chamber heart models have only been addressed recently; most of these works however neglect atrial contraction. Inde…