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physics.bio-ph2025
Topological weight and structural diversity of polydisperse chromatin loop networks
Andrea Bonato, Enrico Carlon, Sergey Kitaev +2
Current biophysical models for transcriptionally active chromatin view this as a polymer with sticky sites, mimicking transcription units such as promoters and enhancers which inte…
physics.bio-ph2023
Topological spectra and entropy of chromatin loop networks
Andrea Bonato, Dom Corbett, Sergey Kitaev +3
The 3D folding of a mammalian gene can be studied by a polymer model, where the chromatin fibre is represented by a semiflexible polymer which interacts with multivalent proteins,…
physics.bio-ph2023
Combinatorics and topological weights of chromatin loop networks
Andrea Bonato, Dom Corbett, Sergey Kitaev +3
Polymer physics models suggest that chromatin spontaneously folds into loop networks with transcription units (TUs), such as enhancers and promoters, as anchors. Here we use combin…