6 citations · 6 across the 1 of their papers we have counts for
3 papers
Modeling Gene Expression Distributional Shifts for Unseen Genetic Perturbations
Kalyan Ramakrishnan, Jonathan G. Hedley, Sisi Qu +5
We train a neural network to predict distributional responses in gene expression following genetic perturbations. This is an essential task in early-stage drug discovery, where suc…
Electric field of DNA in solution: who is in charge?
Jonathan G. Hedley, Kush Coshic, Aleksei Aksimentiev +1
In solution, DNA is a highly charged macromolecule which bears a unit of negative charge on each phosphate of its sugar-phosphate backbone. Although partially compensated by counte…
Nonlocal Structural Effects of Water on DNA Homology Recognition
Ehud Haimov, Jonathan G. Hedley, Alexei A. Kornyshev
The mechanism behind mutual recognition of homologous DNA sequences prior to genetic recombination is one of the remaining puzzles in molecular biology. Leading models of homology…