7 papers
Condition-Gated Reasoning for Context-Dependent Biomedical Question Answering
Jash Rajesh Parekh, Wonbin Kweon, Joey Chan +7
Current biomedical question answering (QA) systems often assume that medical knowledge applies uniformly, yet real-world clinical reasoning is inherently conditional: nearly every…
MedHopQA: A Disease-Centered Multi-Hop Reasoning Benchmark and Evaluation Framework for LLM-Based Biomedical Question Answering
Rezarta Islamaj, Robert Leaman, Joey Chan +13
Evaluating large language models (LLMs) in the biomedical domain requires benchmarks that can distinguish reasoning from pattern matching and remain discriminative as model capabil…
Large Language Models Meet Biomedical Knowledge Graphs for Mechanistically Grounded Therapeutic Prioritization
Chih-Hsuan Wei, Chi-Ping Day, Zhizheng Wang +8
Drug repurposing is often framed as a candidate identification task, but existing approaches provide limited guidance for distinguishing biologically plausible candidates from hist…
DeepER-Med: Advancing Deep Evidence-Based Research in Medicine Through Agentic AI
Zhizheng Wang, Chih-Hsuan Wei, Joey Chan +19
Trustworthiness and transparency are essential for the clinical adoption of artificial intelligence (AI) in healthcare and biomedical research. Recent deep research systems aim to…
Knowledge-guided Contextual Gene Set Analysis Using Large Language Models
Zhizheng Wang, Chi-Ping Day, Chih-Hsuan Wei +9
Gene set analysis (GSA) is a foundational approach for interpreting genomic data of diseases by linking genes to biological processes. However, conventional GSA methods overlook cl…
Enhancing Biomedical Relation Extraction with Directionality
Po-Ting Lai, Chih-Hsuan Wei, Shubo Tian +2
Biological relation networks contain rich information for understanding the biological mechanisms behind the relationship of entities such as genes, proteins, diseases, and chemica…