2 papers
cs.LG2026
Constraint-Aware Optimization for Robust Protein Stability Prediction
A Shivram, Aneesh S. Chivukula, Manik Gupta +1
Multimodal predictors integrating protein language models with inverse-folding representations achieve strong in-distribution accuracy on the Megascale dataset but exhibit…
q-bio.PE2026
Evolutionary and Structural Constraints Define a Mutation-Resistant Catalytic Core in E. coli Serine Hydroxy methyltransferase (SHMT)
Deeptanshu Pandey, Dwipanjan Sanyal, Vladimir N. Uversky +2
Serine hydroxymethyltransferase is an essential enzyme in the Escherichia coli folate pathway, yet it has not been adopted as an antibacterial target, unlike DHFR, DHPS, or thymidy…