4 citations · 7 across the 7 of their papers we have counts for
7 papers
Conditionally Site-Independent Neural Evolution of Antibody Sequences
Stephen Zhewen Lu, Aakarsh Vermani, Kohei Sanno +4
Common deep learning approaches for antibody engineering focus on modeling the marginal distribution of sequences. By treating sequences as independent samples, however, these meth…
Measuring Scientific Capabilities of Language Models with a Systems Biology Dry Lab
Haonan Duan, Stephen Zhewen Lu, Caitlin Fiona Harrigan +5
Designing experiments and result interpretations are core scientific competencies, particularly in biology, where researchers perturb complex systems to uncover the underlying syst…
Aligning Protein Conformation Ensemble Generation with Physical Feedback
Jiarui Lu, Xiaoyin Chen, Stephen Zhewen Lu +4
Protein dynamics play a crucial role in protein biological functions and properties, and their traditional study typically relies on time-consuming molecular dynamics (MD) simulati…
Structure Language Models for Protein Conformation Generation
Jiarui Lu, Xiaoyin Chen, Stephen Zhewen Lu +4
Proteins adopt multiple structural conformations to perform their diverse biological functions, and understanding these conformations is crucial for advancing drug discovery. Tradi…
Cell Morphology-Guided Small Molecule Generation with GFlowNets
Stephen Zhewen Lu, Ziqing Lu, Ehsan Hajiramezanali +4
High-content phenotypic screening, including high-content imaging (HCI), has gained popularity in the last few years for its ability to characterize novel therapeutics without prio…
QGFN: Controllable Greediness with Action Values
Elaine Lau, Stephen Zhewen Lu, Ling Pan +2
Generative Flow Networks (GFlowNets; GFNs) are a family of energy-based generative methods for combinatorial objects, capable of generating diverse and high-utility samples. Howeve…
Screening of Pneumonia and Urinary Tract Infection at Triage using TriNet
Stephen Z. Lu
Due to the steady rise in population demographics and longevity, emergency department visits are increasing across North America. As more patients visit the emergency department, t…