5 citations · 7 across the 5 of their papers we have counts for
5 papers
Assessing the Impact of Intercurrent Events on Power and Sample Size for Estimands with Time-to-Event Endpoints
Daniel J Bratton, Fiona Guillard, Sunita Rehal +1
The precise definition of a primary estimand, accounting for intercurrent events (IEs) as per the ICH E9(R1) addendum, is fundamental to the design and interpretation of clinical t…
Using off-treatment sequential multiple imputation for binary outcomes to address intercurrent events handled by a treatment policy strategy
Sunita Rehal, Nicky Best, Sarah Watts +1
The estimand framework proposes different strategies to address intercurrent events. The treatment policy strategy seems to be the most favoured as it is closely aligned with the p…
The Estimand Framework and Causal Inference: Complementary not Competing Paradigms
Thomas Drury, Jonathan W. Bartlett, David Wright +1
The creation of the ICH E9 (R1) estimands framework has led to more precise specification of the treatment effects of interest in the design and statistical analysis of clinical tr…
Estimation methods for estimands using the treatment policy strategy; a simulation study based on the PIONEER 1 Trial
James Bell, Thomas Drury, Tobias Mütze +6
Estimands using the treatment policy strategy for addressing intercurrent events are common in Phase III clinical trials. One estimation approach for this strategy is retrieved dro…
Estimation of treatment policy estimands for continuous outcomes using off treatment sequential multiple imputation
Thomas Drury, Juan J Abellan, Nicky Best +1
The estimands framework outlined in ICH E9 (R1) describes the components needed to precisely define the effects to be estimated in clinical trials, which includes how post-baseline…