2 papers
q-bio.SC2025
Paused in translation: A model for the transcript length-dependent impact of ribosome-targeting antibiotics
Johannes Keisers, Norbert Kern, Luca Ciandrini
Ribosome-targeting antibiotics, such as chloramphenicol, stall elongating ribosomes during protein synthesis, disrupting mRNA translation. These antibiotic-induced pauses occur sto…
cond-mat.stat-mech2024
Biologically relevant finite-size effects in a driven lattice gas with particle pausing and dynamical defects
Johannes Keisers, Lorenzo Vito Dal Zovo, Norbert Kern +1
In this article we present a comprehensive study of the totally asymmetric simple exclusion process with pausing particles (pTASEP), a model initially introduced to describe RNAP d…