161 citations · 162 across the 4 of their papers we have counts for
4 papers
Self-Optimizing Control of Continuous Processes Based on Reinforcement Learning
Ziqi Zhuo, Junghui Chen, Lei Xie +1
This paper addresses the Self-Optimizing Control (SOC) problem in industrial continuous processes and proposes a Reinforcement-Learning (RL)-based SOC approach to improve dynamic p…
Programmable Virtual Humans Toward Human Physiologically-Based Drug Discovery
You Wu, Philip E. Bourne, Lei Xie
Artificial intelligence (AI) has sparked immense interest in drug discovery, but most current approaches only digitize existing high-throughput experiments. They remain constrained…
AI-driven multi-omics integration for multi-scale predictive modeling of causal genotype-environment-phenotype relationships
You Wu, Lei Xie
Despite the wealth of single-cell multi-omics data, it remains challenging to predict the consequences of novel genetic and chemical perturbations in the human body. It requires kn…
Exploration of Dark Chemical Genomics Space via Portal Learning: Applied to Targeting the Undruggable Genome and COVID-19 Anti-Infective Polypharmacology
Tian Cai, Li Xie, Muge Chen +6
Advances in biomedicine are largely fueled by exploring uncharted territories of human biology. Machine learning can both enable and accelerate discovery, but faces a fundamental h…