3 papers
q-bio.QM2026
TACK: A Statistical Evaluation of Degradation Activity on a Novel TArgeting Chimeras Knowledge Dataset
Stefano Ribes, Nils Dunlop, RocÃo Mercado
Proteolysis-targeting chimeras (PROTACs) represent a promising therapeutic modality that induces targeted protein degradation by hijacking the ubiquitin-proteasome system. However,…
cs.LG2026
QT-Net: Rethinking Evaluation of AI Models in Atomic Chemical Space
Pablo MartÃnez Crespo, Stefano Ribes, Martin Rahm +6
Atomic properties such as partial charges or multipoles encode chemically meaningful information that can inform downstream molecular property prediction, but their evaluation as m…
q-bio.QM2024
Modeling PROTAC Degradation Activity with Machine Learning
Stefano Ribes, Eva Nittinger, Christian Tyrchan +1
PROTACs are a promising therapeutic modality that harnesses the cell's built-in degradation machinery to degrade specific proteins. Despite their potential, developing new PROTACs…